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SA4503 | Potent and selective sigma 1 agonist

SA4503 (165377-44-6) is a potent and selective sigma 1 agonist (σ1 IC50 = 17.4 nM, σ2 IC50 = 1784 nM).1 It has been investigated as a cognition enhancer2,3, antidepressant4,5, anti-addiction agent6, and neuroprotectant7-10.

1) Matsuno et al. (1996), Binding properties of SA4503, a novel and selective sigma 1 receptor agonist; Eur. J. Pharmacol. 306 271
2) Matsuno et al. (1997), SA4503, a novel cognition enhancer with sigma 1 agonistic properties; Behav. Brain Res. 83 221
3) Niitsu et al. (2012), Sigma-1 receptor agonists as therapeutic drugs for cognitive impairment in neuropsychiatric diseases; Curr. Pharm. Des. 18 875
4) Skuza and Rogoz et al. (2002), A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist; Behav. Pharmacol. 13 537<br>
5) Lucas et al. (2008), Further evidence for an antidepressant potential of the selective sigma1 agonist SA4503: electrophysiological, morphological and behavioral studies; Int. J. Neuropsychopharmacol. 11 485
6) Mori et al. (2014), Inhibitory effects of SA4503 on the rewarding effects of abused drugs; Addict. Biol. 19 362
7) Nakazawa et al. (1998), Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures; Neurochem. Int. 32 337
8) Ruscher et al. (2011), The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke; Brain 134(Pt.3) 732
9) Ruscher et al. (2012), Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride on inflammation after stroke; PLoS One. 7 e45118
10) Yamashita et al. (2015), Neuroprotective effects of cutamesine, a ligand of the sigma-1 receptor chaperone, against noise-induced hearing loss; Int. J. Neurosci. Res. 93 788

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Catalog#  10-4219-0005

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Catalog Number:
Potent and selective sigma 1 agonist
Chemical Name:
1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride
Alternate Name:
Molecular Weight:
Molecular Formula:
C23H32N2O2 • 2HCl
Soluble in DMSO (up to 5 mg/ml) or in Water (up to at least 25 mg/ml)..
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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