SAG | Smoothened agonist
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $35.00 | ||
| 5 mg | $95.00 |
SAG (912545-86-9) is a smoothened agonist which binds directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 μM (EC50 for SMO activation is ~ 3 nM).1
References/Citations
1) Chen et al. (2002), Small molecule modulation of Smoothened activity; Proc. Natl. Acad. Sci. USA, 99 1407
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SAG (912545-86-9) is a smoothened agonist which binds directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 μM (EC50 for SMO activation is ~ 3 nM).1
References/Citations
1) Chen et al. (2002), Small molecule modulation of Smoothened activity; Proc. Natl. Acad. Sci. USA, 99 1407
Related products
-
EPPTB | TAAR1 antagonist
From $75.00CAS:1110781-88-8Catalog Number:10-1199Activity:TAAR1 antagonistChemical Name:N-(3-Ethoxy-phenyl)-4-pyrrolidin-1-yl-3-trifluoromethyl-benzamideMolecular Weight:378.4Molecular Formula:C20H21F3N2O2Solubility:Soluble in DMSO (up to 25 mg/ml).Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.Shipping Code:RT -
Palmitoylethanolamide | GPR-55 agonist
From $60.00CAS:544-31-0Catalog Number:10-1297Activity:GPR-55 agonistAlternate Names:PEAChemical Name:N-(2-Hydroxyethyl)palmitamideMolecular Weight:299.49Molecular Formula:C18H37NO2Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.Shipping Code:RT -
NA-Gly | GPR18 agonist
From $60.00CAS:179113-91-8Catalog Number:10-1200Activity:GPR18 agonistAlternate Names:N-ArachidonylglycineChemical Name:N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)glycineMolecular Weight:361.53Molecular Formula:C22H35NO3Solubility:Soluble in DMSO (up to 50 mg/ml).Physical Properties:Beige waxy solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 2 years from date of purchase as supplied. Product is subject to oxidation. Solutions in degassed DMSO may be stored at -20°C for up to 1 month.Shipping Code:Blue Ice
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.