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SAG | Smoothened agonist

SAG (912545-86-9) is a smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine (Cat.# 10-1082). The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 μM (EC50 for SMO activation is ~ 3 nM).1

1) Chen et al. (2002), Small molecule modulation of Smoothened activity; Proc. Natl. Acad. Sci. USA, 99 14071

Focus Biomolecules cell signaling reagent supplier, chemical structure of SAG | Smoothened agonist | CAS 912545-86-9

Catalog#  10-4525

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912545-86-9 (free base)
Catalog Number:
Smoothened agonist
Alternate Names:
Smoothened Agonist
Chemical Name:
3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiiophene-2-carboxamide dihydrochloride
Molecular Weight:
Molecular Formula:
C28H28ClN3OS 2HCl
Soluble in DMSO (up to 20 mg/ml), in DMF (up to 20 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Storage Temperature:
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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