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Salermide | SIRT1 and SIRT2 inhibitor

Salermide (1105698-15-4) is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.1 Displays protective effect in nematodes expressing muscular dystrophy protein.2 Promotes neuronal apoptosis confirming the protective effect of SIRT1.3

References/Citations

1) Lara et al. (2009), Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect; Oncogene, 28 781
2) Pasco et al. (2010), Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues; J. Med. Chem., 53 1407
3) Zhao et al. (2012), Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo; Exp. Neurol., 237 489/p>

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Salermide | 1105698-15-4 | Structure | Supplier

Catalog#  10-1514-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1105698-15-4
Catalog Number:
10-1514
Activity:
Inhibitor of SIRT1 and SIRT2
Chemical Name:
N-[3-[[(2-Hydroxy-1-naphthalenyl)methylene]amino]phenyl]-α-methylbenzeneacetamide
Molecular Weight:
394.47
Molecular Formula:
C26H22N2O2
Solubility:
Soluble in DMSO (up to 40 mg/ml), in DMF (up to 30 mg/ml) or in ethanol (up to 10 mg/ml with warming).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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