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Salermide | SIRT1 and SIRT2 inhibitor

Salermide (1105698-15-4) is a SIRT1 and SIRT2 inhibitor. Exhibits a stronger inhibitory effect on SIRT2 than on SIRT1 in vitro. Induces the reactivation of proapoptotic genes repressed by SIRT1 and causes massive apoptosis in cancer cells within 24 hours.1 Displays protective effect in nematodes expressing muscular dystrophy protein.2 Promotes neuronal apoptosis confirming the protective effect of SIRT1.3


1) Lara et al. (2009), Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect; Oncogene, 28 781
2) Pasco et al. (2010), Characterization of sirtuin inhibitors in nematodes expressing a muscular dystrophy protein reveals muscle cell and behavioral protection by specific sirtinol analogues; J. Med. Chem., 53 1407
3) Zhao et al. (2012), Interactions between SIRT1 and MAPK/ERK regulate neuronal apoptosis induced by traumatic brain injury in vitro and in vivo; Exp. Neurol., 237 489/p>

Focus Biomolecules cell signaling supplier, chemical structure of Salermide | SIRT1 & SIRT2 inhibitor | CAS 1105698-15-4

Catalog#  10-1514-0005

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Catalog Number:
Inhibitor of SIRT1 and SIRT2
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 40 mg/ml), in DMF (up to 30 mg/ml) or in ethanol (up to 10 mg/ml with warming).
Physical Properties:
Yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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