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Salubrinal | eIF2a Phosphatase inhibitor

Salubrinal (405060-95-9) is an endoplasmic reticulum (ER) stress inhibitor. It is a selective inhibitor of cellular complexes that dephosphorylate eukaryotic initiation factor 2 subunit alpha (eIF2α).1 It has been found to interact with the anti-apoptotic protein Bcl-2 offering protection from the apoptotic and autophagic effects that result from loss of Bcl-2 function.2 Salubrinal blocked NFATc1 expression and osteoclast differentiation by RANKL via phosphorylation of eLF2α resulting in a decrease of global protein synthesis. It efficiently blocked osteoporosis in a mouse model treated with RANKL.3

References/Citations
1) Boyce et al. (2005) A selective inhibitor of eIF2α dephosphorylation protects cells from ER stress; Science, 307 935
2) Kessel (2006) Protection of Bcl-2 by salubrinal; Biochem. Biophys. Res. Commun., 346 1320
3) He et al. (2013) Osteoporosis regulation by salubrinal through eFI27alpha; mediated differentiation of osteoclast and osteoblast; Cell. Signal., 25 552

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Focus Biomolecules reagent supplier, chemical structure of Salubrinal | eIF2a Phosphatase inhibitor | CAS 405060-95-9

Catalog#  10-4517

$80.00
Quantity
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CAS:
405060-95-9
Catalog Number:
10-4517
Activity:
eIF2α Phosphatase inhibitor
Chemical Name:
3-Phenyl-N-[2,2,2-trichloro-1-[[(8-quinolinylamino)thioxomethyl]amino]ethyl]-2-propenamide
Molecular Weight:
479.81
Molecular Formula:
C21H17Cl3N4OS
Solubility:
Soluble in DMSO (up to 25 mg/ml),
Physical Properties:
Beige solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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