my account
Login
  Loading... Please wait...

Product Details

SB 202190 | p38 MAP kinase inhibitor

SB 202190 (152121-30-7) is a potent and selective p38 MAP kinase inhibitor acting at the ATP site.1 Selectively inhibits the p38α and β isoforms (IC50= 50 and 100 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively).2 SB 202190 effectively blocks LPS-induced gene expression in monocytes.3 Induces apoptosis.4 Cell permeable.

References/Citations
1) Young et al. (1997), Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site; J. Biol. Chem., 272 12116
2) Davies et al. (2000), ,i>Specificity and mechanism of action of some commonly used protein kinase inhibitors; Biochem. J., 351 95
3) Manthey et al. (1998), SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRBAs in monocytes; J. Leukoc. Biol., 64 409
4) Nemoto et al. (1998), Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase; J. Biol. Chem., 273 16415

swipe
Image 1

Catalog#  10-2172

$75.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
152121-30-7
Catalog Number:
10-2172
Activity:
p38 MAP kinase inhibitor
Chemical Name:
4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol
Molecular Weight:
331.35
Molecular Formula:
C20H14N3OF
Solubility:
Soluble in DMSO (up to 30 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the SB 202190 | p38 MAP kinase inhibitor to your wish list.