SB-405483 | Allosteric cereblon ligand

CAS:
 N/A
Catalog Number:
 10-3983
SB-405483 chemical structure

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SB-405483 binds to an allosteric site on cereblon (CRBN) enhancing the binding of other cereblon ligands and altering their degradation profiles.

Referencesw/Citations:

  1. Dippon et al. (2026), Identification of an allosteric site on the E3 ligase adapter cereblon; Nature 651 482
Allosteric cereblon ligand, SB-405483, SB-405483 supplier, SB405483
CAS:
N/A
Catalog Number:
10-3983
Activity:
Allosteric cereblon ligand
Chemical Names:
1-(3-(Benzyloxy)pyridine-2-yl)-3-(4-cyano-2-hydroxyphenyl)urea
Molecular Weight:
360.37
Molecular Formula:

C20H16N4O3

Solubility:
Soluble in DMSO (at least 50 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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SB-405483 binds to an allosteric site on cereblon (CRBN) enhancing the binding of other cereblon ligands and altering their degradation profiles.

Referencesw/Citations:

  1. Dippon et al. (2026), Identification of an allosteric site on the E3 ligase adapter cereblon; Nature 651 482

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