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Product Details

SC-560 | Selective COX-1 inhibitor

SC-560 (188817-13-2) is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNF α-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50’s = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells – it remained COX-1 specific in cell lysates.2

References/Citations

1) Smith et al. (1998), Pharmacological analysis of cyclooxygenase-1 in inflammation; Proc. Natl. Acad. Sci. USA 95 13313
2) Brenneis et al. (2006), Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition; FASEB J. 20 1352

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Catalog#  10-2531

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
18817-13-2
Catalog Number:
10-2531
Activity:
Selective COX-1 inhibitor
Chemical Name:
5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Molecular Weight:
352.74
Molecular Formula:
C17H12ClF3N2O
Solubility:
Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Brown solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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