my account
Login
  Loading... Please wait...

Product Details

SC-79 | AKT activator

Akt activator. Binds to the pleckstrin homology domain of Akt preventing membrane translocation but paradoxically activating it in the cytosol. Enhances Akt phosphorylation by upstream protein kinases. Suppresses excitotoxicity-induced neuronal death in vitro and in vivo.1 A useful tool for studying the PI3K/Akt axis.

References/Citations
1) Jo et al. (2012), Small-molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death; Proc. Natl. Acad. Sci. USA, 109 10581
2) Yang et al. (2016), MiR-221 Promotes Capan-2 Pancreatic Ductal Adenocarcinoma Cells Proliferation by Targeting PTEN-Akt; Cell. Physiol. Biochem. 38 2366
3) Chen et al. (2017), Novel Akt activator SC-79 is a potential treatment for alcohol-induced osteonecrosis of the femoral head; Oncotarget, 8 31065

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of SC-79 | AKT activator | CAS 305834-79-1

Catalog#  10-1468

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
305834-79-1
Catalog Number:
10-1468
Activity:
AKT activator
Chemical Name:
2-Amino-6-chloro-_-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester
Molecular Weight:
364.79
Molecular Formula:
C17H17ClN2O5
Solubility:
Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 40 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the SC-79 | AKT activator to your wish list.