my account
Login
  Loading... Please wait...

Product Details

SI-2 | Potent inhibitor of steroid receptor coactivator-3 (SRC-3)

Si-2 (380537-35-9) is a potent inhibitor of steroid receptor coactivator-3 (SRC-3).1 It blocks MDA-MB-468 cell growth with an IC50 = 3.4 nM without effecting normal cells.1 It significantly inhibited breast cancer cell growth in an orthotopic MDA-MD-468 mouse model. Treatment of MCF-7 or triple negative MDA-MB-231 cells with SI-2 resulted in inhibition of proliferation and breast cancer stem cell (CSC) tumorsphere formation.2 CSC markers CD44+/CD24-/1o and aldehyde dehydrogenase (ALDH) were also reduced indicating that SI-2 can selectively interfere with the TIC/CSC state in breast cancer cells.2,3

References/Citations
1) Song et al. (2016), Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3; Proc. Natl. Acad. Sci. USA 113 4970
2) Rohira et al. (2017), Targeting SRC Coactivators Blocks the Tumor-Initiating Capacity of Cancer Stem-like Cells; Cancer Res. 77 4293
3) Truong et al. (2018), Cancer Stem Cell Phenotypes in ER+ Breast Cancer Models are Promoted by PELP/AIB1 Complexes; Mol. Cancer Res. 16 707

swipe
Image 1

Catalog#  10-3903-0005

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
380537-35-9
Catalog Number:
10-3903
Activity:
Potent inhibitor of steroid receptor coactivator-3 (SRC-3)
Chemical Name:
1-Methyl-N-[(E)-1-pyridin-2-ylethylideneamino]benzimidazole-2-amine
Molecular Weight:
265.31
Molecular Formula:
C15H15N5
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Pale orange solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the SI-2 | Potent inhibitor of steroid receptor coactivator-3 (SRC-3) to your wish list.