Two recent papers employed Sinefungin in determination of the structure of two different viral methyltransferases. Sinefungin is a Streptomyces natural product analog of S-adenosylmethionine acting as a MTase inhibitor.
In an Antiviral Research paper by DS Ferrero and coworkers, the Usutu virus MTase domain was cocrystalized with Sinefungin.
In another paper by Kottur and coworkers in Nature Structural & Molecular Biology, the group cocrystalized SARS-CoV-2 N7 MTase bound to Sinefungin. In both papers valuable structural information was obtained which will guide the development of new antiviral therapeutics.
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