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SirtAct | Sirt1 activator

SirtAct (839699-72-8) is a Sirt1 activator (233% at 10 μM)1 Suppresses TNFα release from THP-1 cells and stimulates adipogenesis in 3T3L1 cells1. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice2. SirtAct inhibits NFκB activation and reduces inflammatory cytokine production in lamina propria mononuclear cells from IBD patients3. Prevents and cures experimental colitis in a mouse model3.

References/Citations
1) Nayagam et al. (2006), SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin sensitizing agents; J. Biomol. Screen., 11 959
2) Barbieri et al. (2012), Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner; Circulation, 126 1373
3) Caruso et al. (2014), Defective expression of SIRT1 contributes to sustain inflammatory pathways in the gut; Mucosal Immunol., May 21 Epub.

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Focus Biomolecules cell signaling reagent supplier, chemical structure of SirtAct | SIRT1 activator | CAS 839699-72-8

Catalog#  10-2595

$80.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
839699-72-8
Catalog Number:
10-2595
Activity:
Sirt1 activator
Alternate Names:
CAY10591
Chemical Name:
2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide
Molecular Weight:
367.46
Molecular Formula:
C20H25N5O2
Solubility:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Olive green solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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