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SKF525A HCl | Cytochrome P450 inhibitor

SKF-525A (62-68-0) is a commonly used non-selective Cytochrome P450 inhibitor.1  It is also a local anesthetic2 acting via blockage of the acetylcholine receptor3 – it is a commonly used reagent to stabilize the desensitized state of muscle AChR4.  SKF-525A also inhibits glibenclamide-sensitive K+ channels.5

References/Citations

1) Franklin and Hathaway (2008) 2-Diethylaminoethyl-2,2-diphenylvalerate-HCL (SKF525A) revisited: comparative cytochrome P450 inhibition in human liver microsomes by SKF525A, its metabolites, and SKF-acid and SKF-alcohol; Drug Metab. Dispos, 36 2539
2) Suarez-Kurtz and Bianchi (1970) Sites of action of SKF-525A in nerve and muscle; J. Pharmacol. Exp. Ther., 172 33
3) Spitzmaul et al. (2009) The local anesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms; Br. J. Pharmacol., 157 804
4) Prince and Sine (1999) Acetylcholine and epibatidine binding to muscle acetylcholine receptors distinguish between concerted and uncoupled models; J. Biol. Chem., 274 19623
5) Sakust and Yoneda (1994) Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes; Eur. J. Pharmacol., 252 117

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Focus Biomolecules cell signaling reagent supplier, chemical structure SKF525A HCl | Cytochrome P450 inhibitor | CAS 62-68-0

Catalog#  10-4050

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
62-68-0
Catalog Number:
10-4050
Activity:
Cytochrome P450 inhibitor
Chemical Name:
N,N,Diethylaminoethyl 2,2diphenylvalerate hydrochloride
Alternate Names:
Proadifen
Molecular Weight:
389.96
Molecular Formula:
C23H31NO2 &bul; HCl
Solubility:
Soluble in DMSO (up to 20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98%
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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