SKL2001 | Wnt/ß-Catenin pathway activator

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SKL2001 (909089-13-0) is a Wnt/ß-catenin pathway activator that disrupts the Axin/ß-catenin interaction leading to ß-catenin stabilization.1 It suppressed colon cancer spheroid growth via regulation of the E-cadherin/ß-catenin complex.2 A commonly used reagent to reactivate or rescue the Wnt/ß-Catenin signaling pathway.3,4

References/CItations:

  1. Gwak et al. (2012), Small molecule-based disruption of the Axin/ß-catenin protein complex regulates mesenchymal stem cell differentiation; Cell Res. 22 237
  2. Ohashi et al. (2017), SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/ß-Catenin complex; Biochem. Biophys. Res. Commun. 493 1342
  3. Xiang et al. (2020), Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3ß/ß-Catenin pathway; Biosci. Rep. 40 BSR20201578
  4. Liu et al. (2022), Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/ß-catenin signaling pathway; Drug Dev. Res. 83 952
909089-13-0, Axin/ß-catenin interaction inhibitor, SKL 2001, SKL2001 supplier, SKL2011, Wnt pathway activator

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

SKL2001 (909089-13-0) is a Wnt/ß-catenin pathway activator that disrupts the Axin/ß-catenin interaction leading to ß-catenin stabilization.1 It suppressed colon cancer spheroid growth via regulation of the E-cadherin/ß-catenin complex.2 A commonly used reagent to reactivate or rescue the Wnt/ß-Catenin signaling pathway.3,4

References/CItations:

  1. Gwak et al. (2012), Small molecule-based disruption of the Axin/ß-catenin protein complex regulates mesenchymal stem cell differentiation; Cell Res. 22 237
  2. Ohashi et al. (2017), SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/ß-Catenin complex; Biochem. Biophys. Res. Commun. 493 1342
  3. Xiang et al. (2020), Lnc GNG12-AS1 knockdown suppresses glioma progression through the AKT/GSK-3ß/ß-Catenin pathway; Biosci. Rep. 40 BSR20201578
  4. Liu et al. (2022), Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/ß-catenin signaling pathway; Drug Dev. Res. 83 952

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