SLU-PP-332 | ERR pan-agonist/Exercise mimetic
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 10 mg | $65.00 | ||
| 50 mg | $230.00 |
SLU-PP-332 (303760-60-3) is a pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM) with highest potency for ERRα.1,2 SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line.2 It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.2
References/Citations:
- Lin et al. (2018), Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists; Bioorg. Med. Chem. Lett., 28 1313
- Billon et al. (2023), Synthetic ERRα/ß/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity; ACS Chem. Biol., 18 756
C18H14N2O2
>98% by HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SLU-PP-332 (303760-60-3) is a pan-agonist of the estrogen receptor-related receptors (EC50’s cell-based cotransfection/reporter assay: ERRα = 98 nM, ERRß = 230 nM, ERRγ = 430 nM) with highest potency for ERRα.1,2 SLU-PP-332 increased mitochondrial function and cellular respiration in a skeletal muscle cell line.2 It also increased fast oxidative skeletal muscle fibers (Type IIa) and exercise endurance in mice in an ERRα-specific manner. SLU-PP-332 activates an acute aerobic exercise genetic response via inducing the expression of DDIT4.2
References/Citations:
- Lin et al. (2018), Design, synthesis, and evaluation of simple phenol amides as ERRγ agonists; Bioorg. Med. Chem. Lett., 28 1313
- Billon et al. (2023), Synthetic ERRα/ß/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity; ACS Chem. Biol., 18 756
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