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Product Details

SMED-1 | Dexamethasone sensitizer

A dexamethasone (Dex) sensitizer. SMED-1 was discovered in a screen designed to identify compounds that sensitize Dex-resistant ALL xenografts to Dex.1 The assay employed Dex-resistant ALL-19 cells which are resistant at concentrations up to 850 μM. In contrast ALL-3 cells are sensitive to nanomolar concentrations of Dex (IC50=12 nM).2 SMED-1 displays strong synergism at 10 μM plus 1 mM Dex and exhibits little activity alone (IC50>20 μM). SMED-1 is Dex-synergistic in ALL-3, ALL-4 and ALL-16 xenografts but is antagonistic with ALL-31. Synergy is highest when drugs are given simultaneously.1


1) Toscan et al. (2014), High-throughput screening of human leukemia xenografts to identify dexamethasone sensitizers; J. Biomol. Screen., 19 1391
2) Liem et al. (2004), Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies; Blood, 103 3905

Focus Biomolecules cell signaling reagent supplier, chemical structure of SMED-1 | Dexamethasone sensitizer

Catalog#  10-1606

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Catalog Number:
Dexamethasone sensitizer
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml), DMF (up to 30 mg/ml), or Ethanol (up to 20 mg/ml)
Physical Properties:
Pale grey solid
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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