my account
  Loading... Please wait...

Product Details

SNS-314 mesylate | Aurora kinase inhibitor

SNS-314 mesylate (1146618-41-8) is a potent and selective pan-Aurora kinase inhibitor (IC50’s: Aurora A = 9 nM, Aurora B = 31 nM, Aurora C = 3 nM.1,2 It was able to inhibit proliferation in a wide panel of human cancer cell lines including colon (HCT116), breast (MDA-MB-231), prostate (PC-3), lung (H1299, Calu-6), ovarian (A2780), melanoma (A375) and liver (SMMC-7721, HepG2, LM6).1-4

1) Oslob et al. (2008) Discovery of a potent and selective aurora kinase inhibitor; Bioorg. Med. Chem. Lett. 18 4880
2) Arbitrario et al. (2010) SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo; Cancer Chemother. Pharmacol. 65 707
3) VanderPorten et al. (2009) The Aurora kinase inhibitor SNS-314 shows broad therapeutic potential with chemotherapeutics and synergy with microtubule-targeted agents in a colon carcinoma model; Mol. Cancer Ther. 8 930
4) Liu et al. (2017) Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma; Oncotarget 8 27953

Image 1

Catalog#  10-4779-0005

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
Request Bulk Quote
Catalog Number:
Aurora kinase inhibitor
Chemical Name:
1-(3-Chlorophenyl)-3-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl]urea mesylate
Molecular Weight:
Molecular Formula:
C18H15ClN6OS2 • CH3SO3H
Soluble in DMSO (up to at least 25 mg/ml).
Physical Properties:
Off-white solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the SNS-314 mesylate | Aurora kinase inhibitor to your wish list.