Spastazoline | Spastin inhibitor

Spastazoline chemical structure

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Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin.  It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2).  It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.

References/Citations:

  1. Cupido et al. (2019), Designing a chemical inhibitor for the AAA protein spastin using active site mutations; Nat. Chem. Biol. 15 444
  2. Yang et al. (2023), Inhibition of spastin impairs motor function recovery after spinal cord injury; Brain Res. Bull. 205 110806
  3. Liu et al. (2024), 14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention; eLife 12 RP90184
2351882-11-4, Spastazoline, Spastazoline supplier, Spastin inhibitor
Alternate Name:
Racemetyrosine HCl; DL-alpha-methyltyrosine HCl

Safety Data Sheet:

N/A

Product Data Sheet:

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Spastazoline (2351882-11-4) in as ATP-competitive inhibitor (IC50 = 99 nM) of the microtubule-severing AAA protein spastin.  It is selective against four related AAA proteins (XL-katarin, Hs-FIGL1, Mm-VCP, and Hs-PCH2).  It impaired recovery of motor function in a mouse model of spinal cord injury.2 Reverses the effects of 14-3-3 agonist Fusicoccin A on neurite outgrowth and regeneration in vitro.3 A new and interesting tool for the study of the assembly, disassembly, or maintenance of microtubule-based cellular structures.

References/Citations:

  1. Cupido et al. (2019), Designing a chemical inhibitor for the AAA protein spastin using active site mutations; Nat. Chem. Biol. 15 444
  2. Yang et al. (2023), Inhibition of spastin impairs motor function recovery after spinal cord injury; Brain Res. Bull. 205 110806
  3. Liu et al. (2024), 14-3-3 protein augments the protein stability of phosphorylated spastin and promotes the recovery of spinal cord injury through its agonist intervention; eLife 12 RP90184

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