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Product Details

Sphingosine | PKC inhibitor

Sphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4

References/Citations
1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds; Biochemistry, 28 3138
2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling; Cell. Mol. Life Science, 58 2053
3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites; Pharm. Res., 47 383
4) Olivier (2002) Sphingosine in apoptosis signaling; Biochim. Biophys. Acta, 1585 153

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Sphingosine | PKC inhibitor | CAS 123-78-4

Catalog#  10-2287

$70.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
123-78-4
Catalog Number:
10-2287
Activity:
PKC inhibitor
Chemical Name:
(2S,3R,4E)-2-Amino-4-octadecene-1,3-diol
Molecular Weight:
299.5
Molecular Formula:
C18H37NO2
Solubility:
Soluble in DMSO (up to 5 mg/ml, with warming) or in Ethanol (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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