SPHINX | SRPK1 inhibitor

CAS:
 848057-98-7
Catalog Number:
 10-3044
SPHINX chemical structure

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SPHINX (848057-98-7) is a potent inhibitor of SRPK1 (Serine/arginine-rich protein kinase 1), IC50 = 0.88 µM which is selective over SRPK2 (IC50 > 10 µM).1 SRPK1 is a splice factor kinase which drives the activity of splice factors such as SRSF1. Inhibition of SRPK1 by SPHINX in K561 leukemia and PC3 prostate cancer cell lines reduced cell proliferation, invasion and migration.2 In combination with azacitidine, SPHINX reduced viability and increased apoptosis in the acute myeloid leukemia cell line Kasumi-1.3

References/Citations:

  1. Gammons et al. (2013), Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD; Invest. Ophthamol. Vis. Sci. 54 6052
  2. Belali et al. (2020), WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1; Biochim. Biophys. Acta Gene Regul. Mech. 1863 194642
  3. Wodi et al. (2023), SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia; Br. J. Biomed. Sci. 80 11041
848057-98-7, SPHINX, SPHINX SRPK1, SPHINX supplier, SRPK1 inhibitor
CAS:
848057-98-7
Catalog Number:
10-3044
Activity:
SRPK1 inhibitor
Chemical Names:
5-Methyl-N-[2-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-2-furancarboxamide
Molecular Weight:
354.33
Molecular Formula:

C17H17F3N2O3

Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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SPHINX (848057-98-7) is a potent inhibitor of SRPK1 (Serine/arginine-rich protein kinase 1), IC50 = 0.88 µM which is selective over SRPK2 (IC50 > 10 µM).1 SRPK1 is a splice factor kinase which drives the activity of splice factors such as SRSF1. Inhibition of SRPK1 by SPHINX in K561 leukemia and PC3 prostate cancer cell lines reduced cell proliferation, invasion and migration.2 In combination with azacitidine, SPHINX reduced viability and increased apoptosis in the acute myeloid leukemia cell line Kasumi-1.3

References/Citations:

  1. Gammons et al. (2013), Topical antiangiogenic SRPK1 inhibitors reduce choroidal neovascularization in rodent models of exudative AMD; Invest. Ophthamol. Vis. Sci. 54 6052
  2. Belali et al. (2020), WT1 activates transcription of the splice factor kinase SRPK1 gene in PC3 and K562 cancer cells in the absence of corepressor BASP1; Biochim. Biophys. Acta Gene Regul. Mech. 1863 194642
  3. Wodi et al. (2023), SPHINX-Based Combination Therapy as a Potential Novel Treatment Strategy for Acute Myeloid Leukaemia; Br. J. Biomed. Sci. 80 11041

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