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Product Details

Splitomicin | Sirt1 inhibitor

Splitomycin (5690-03-9) was initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Splitomycin inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.

References/Citations
1) Bedalov et al. (2001), Identification of a small molecule inhibitor of Sir2p; Proc. Natl. Acad. Sci. USA, 98 15113
2) Biacsi et al. (2008), SIRT1 inhibition alleviates gene silencing in Fragile X mental retardation syndrome; PLoS Genet., 4(3) e1000017
3) Nadtochiy et al. (2011), Lysine deacetylation in ischaemic preconditioning: the role of SIRT1; Cardiovasc. Res., 89 643

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Catalog#  10-2615

$48.00
Quantity
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CAS:
1382877
Catalog Number:
10-2615
Activity:
Sirt1 inhibitor
Chemical Name:
1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Molecular Weight:
198.22
Molecular Formula:
C13H10O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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