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SR-9009 | RevErb alpha & beta agonist

SR-9009 (1379686-30-2) is an agonist at nuclear receptor Rev-ErbA1. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model2. SR-9009 suppresses atherosclerosis in a mouse model3.  Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues.4 Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.5

1) Solt et al. (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists; Nature, 485 62
2) Li et al. (2014) A study on circadian rhythm disorder of rat lung tissue caused by mechanical ventilation induced lung injury; Int.Immunopharmacol. 18 249
3) Sitaula et al. (2015) Suppression of atherosclerosis by synthetic REV-ERB agonist; Biochem. Biophys. Res. Commun., 460 566
4) Sulli et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence; Nature, 553 351
5) Das et al. (2018) Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain; Gene 655 1

Focus Biomolecules supplier, chemical structure of SR-9009 | RevErb alpha & beta agonist | CAS 1379686-30-2

Catalog#  10-1511

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Catalog Number:
RevErbα/β agonist
Chemical Name:
Ethyl 3-(((4-chlorobenzyl)((5-nitrophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate hydrochloride
Molecular Weight:
Molecular Formula:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Tan solid
98% by TLC
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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