SR1 | Maintains stem cells in pluripotent state
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 1 mg | $35.00 | ||
| 5 mg | $90.00 |
SR1 (1227633-49-9) extends the pluripotency of hematopoietic stem cells by antagonizing the arylhydrocarbon receptor (AhR), IC50 = 127 nM.1 The effect is dose-dependent and reversible. Displays a biphasic effect on CD34-negative cells with low does (1 µM) enhancing proliferation and high does (>5 µM) repressing proliferation.2 May be used to generate progenitor T cells3 from HSPCs as well as NK cells for immuno-oncology studies4.
References/Citations:
1) Boitano et al. (2010), Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science, 329 1354
2) Tao et al. (2017), StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells; J. Stem Cells Regen. Med., 13 75
3) Singh et al. (2019), Generation and function of progenitor T cells from stemRegenin-1-expanded CD34+ human hematopoietic progenitor cells; Blood Adv, 3 2934
4) Hoogstad-van Evert et al. (2017), Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice; Oncoimmunology, 6(8) e1320630
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
SR1 (1227633-49-9) extends the pluripotency of hematopoietic stem cells by antagonizing the arylhydrocarbon receptor (AhR), IC50 = 127 nM.1 The effect is dose-dependent and reversible. Displays a biphasic effect on CD34-negative cells with low does (1 µM) enhancing proliferation and high does (>5 µM) repressing proliferation.2 May be used to generate progenitor T cells3 from HSPCs as well as NK cells for immuno-oncology studies4.
References/Citations:
1) Boitano et al. (2010), Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells; Science, 329 1354
2) Tao et al. (2017), StemRegenin 1 selectively promotes expansion of Multipotent Hematopoietic Progenitors derived from Human Embryonic Stem Cells; J. Stem Cells Regen. Med., 13 75
3) Singh et al. (2019), Generation and function of progenitor T cells from stemRegenin-1-expanded CD34+ human hematopoietic progenitor cells; Blood Adv, 3 2934
4) Hoogstad-van Evert et al. (2017), Umbilical cord blood CD34+ progenitor-derived NK cells efficiently kill ovarian cancer spheroids and intraperitoneal tumors in NOD/SCID/IL2Rgnull mice; Oncoimmunology, 6(8) e1320630
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