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Product Details

SR9243 | LXR inverse agonist

SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression.1 Induces apoptosis in a variety of cancer cell types including SW620 (IC50 = 40 nM), HT-29 (IC50 = 104 nM), DU-145 (IC50 = 15 nM), PC-3 (IC50 = 61 nM), NCI-H23 (IC50 = 72 nM), HOP-62 (IC50 = 26 nM) and MIAPACA-2 (IC50= 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.

References/Citations
1) Flaveny et al. (2015), Broad anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis; Cancer Cell, 28 42

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Catalog#  10-4579

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1613028-81-1
Catalog Number:
10-4579
Activity:
LXR inverse agonist
Chemical Name:
N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3Õ-(methylsulfonyl)[1,1Õ-biphenyl]-4-yl]methyl]-benzenesulfonamide
Molecular Weight:
626.62
Molecular Formula:
C31H32BrNO4S2
Solubility:
Soluble in DMSO (greater than 25 mg/ml)
Physical Properties:
White solid
Purity:
>98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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