Stauprimide (154589-96-5) dramatically primes embryonic stem cells for differentiation. Its molecular target is NME2, a c-Myc-activating transcription factor. Stauprimide inhibits nuclear localization of NME2 thereby downregulating c-Myc.3
References/Citations
1) Zhu et al. (2009), A small molecule primes embryonic stem cells for differentiation; Cell Stem Cell, 4 416
2) Zaret et al. (2009), Using small molecules to great effect in stem cell differentiation; Cell Stem Cell, 4 373
3) Bouvard et al. (2017) Small molecule selectively suppresses MYC transcription in cancer cells; Proc. Natl. Acad. SCi. USA 114 3497
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