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STF-083010 | Inhibits IRE1

STF-083010 (307543-71-1) is a novel small molecule inhibitor of IRE1. It inhibits IRE1 endonuclease activity but not its kinase activity after endoplasmic reticulum stress1-3. It displays significant antimyeloma activity in model human MM xenografts1. STF-083010 induces apoptosis in pancreatic cancer cells and displays growth inhibition in a clonogenic growth assay in soft agar as well as in a xenograft in vivo model of pancreatic cancer4. Active in vivo.

References/Citations
1) Papandreou et al. (2011), Identification of an Ire1α endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma; Blood, 117 1311
2) Wang et al. (2012), Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors; Nature Chem. Biol., 8 982
3) Tam et al. (2014), Ire1 has distinct catalytic mechanisms for XBP/HAC1 splicing and RIDD; Cell Rep., 9 850
4) Chien et al. (2014), Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells; Oncotarget, 5 4881

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Focus Biomolecules cell signaling reagent supplier, chemical structure of STF-083010 | IRE1 inhibitor | CAS 307543-71-1

Catalog#  10-1510

$45.00
Quantity
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CAS:
307543-71-1
Catalog Number:
10-1510
Activity:
Inhibits IRE1
Chemical Name:
N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
Molecular Weight:
317.39
Molecular Formula:
C15H11NO3S2
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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