STING Degrader 1 | STING PROTAC

STING Degrader 1 chemical structure

Available Options

Size:PriceQuantity 
1 mg$110.00
5 mg$250.00
Request Quote / Bulk / Custom Size
Product Inquiry

STING degrader 1 (2762552-74-7) is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING). This degrader was designed by coupling C-170, a small molecule STING inhibitor with pomalidomide via a C-6 linker. It selectively degrades STING with a DC50=3.2 µM.1 It displays antiinflammatory activity in a cisplatin-induced acute kidney injury mouse model.1 Caution: May be teratogenic. Pregnant women should avoid all contact with this substance.

References/Citations:

  1. Liu et al. (2022), Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy; J. Med. Chem., 65 6593
2762552-74-7, SP23, STING degrader 1, STING PROTAC
Alternate Name:
SP23

Safety Data Sheet:

N/A

Product Data Sheet:

Download Product Data Sheet

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

STING degrader 1 (2762552-74-7) is a CRBN-based PROTAC degrader that recruits the cereblon-containing E3 ubiquitin ligase to direct the proteasomal degradation of the Stimulator of Interferon Genes (STING). This degrader was designed by coupling C-170, a small molecule STING inhibitor with pomalidomide via a C-6 linker. It selectively degrades STING with a DC50=3.2 µM.1 It displays antiinflammatory activity in a cisplatin-induced acute kidney injury mouse model.1 Caution: May be teratogenic. Pregnant women should avoid all contact with this substance.

References/Citations:

  1. Liu et al. (2022), Novel CRBN-Recruiting Proteolysis-Targeting Chimeras as Degraders of Stimulator of Interferon Genes with In Vivo Anti-Inflammatory Efficacy; J. Med. Chem., 65 6593