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Streptozotocin | Diabetes inducer

Streptozotocin (18883-66-4) is an N-nitroso-aminoglucose derivative which is used to produce animal models of diabetes.1 Alkylates DNA.2 Inhibits pancreatic β-cell O-Glc-NAc selective N-acetyl-β-D-glucosaminidase.3  Selectively induces death of β-cells which mechanistically is independent of N-acetyl-β-D-glucosaminidase inhibition.4 Streptozotocin is not a spontaneous NO donor.5

References/Citations

1) Szkudelski et al. (2001), The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas.; Physiol. Res., 50 537
2) Bennett & Pegg (1981), Alkylation of DNA in rat tissues following administration of streptozotocin; Cancer Res., 41 27861
3) Konrad et al. (2001), The potential mechanism of the diabetogenic action of streptozotocin inhibition of pancreatic beta-cell O-GlcNAc-selective N-acetyl-beta-D-glucosaminidase; Biochem. J., 356 Pt 1 31
4) Gao et al. (2000), Streptozotocin-induced beta-cell death is independent of its inhibition of O-GlcNAcase in pancreatic Min6 cells; Arch. Biochem. Biophys., 383 296
5) Kroncke & Kolb-Bachofen (1996), Streptozotocin is not a spontaneous NO donor.; Free Radic. Res., 24 77

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Streptozotocin | Diabetes inducer | CAS 18883-66-4

Catalog#  10-2127-0001

$100.00
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CAS:
18883-66-4
Catalog Number:
10-2127
Activity:
Diabetes inducer
Chemical Name:
2-Deoxy-2-[[(methylnitrosoamino)carbonyl]amino]-D-glucose
Alternate Names:
Streptozocin; U-9889
Molecular Weight:
265.22
Molecular Formula:
C8H15N3O7
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Water (up to 25 mg/ml)
Physical Properties:
Off-white solid
Purity:
97% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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