SU0617 | SMUG1 inhibitor

CAS:
 N/A
Catalog Number:
 10-4995

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SU0617 is a first-in-class inhibitor of the DNA base excision repair (BER) enzyme SMUG1 (IC50 = 1.5 µM).1 It also displays significant inhibition of another BER enzyme, NTHL1.

References/Citations:

  1. Thacker al. (2026), A SMUG1 Inhibitor Modulates the Excision of Pyrimidine DNA Damage; ACS Med. Chem. Lett., 17 1285
SMUG1 inhibitor, SU-0617, SU0617, SU0617 supplier
CAS:
N/A
Catalog Number:
10-4995
Activity:
SMUG1 inhibitor
Chemical Names:
N-(4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenyl)nicotinamide
Molecular Weight:
406.89
Molecular Formula:

C21H15ClN4OS

Solubility:
Soluble in DMSO (35 mg/ml)
Physical Properties:
Light gray solid
Purity:

>97% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

SU0617 is a first-in-class inhibitor of the DNA base excision repair (BER) enzyme SMUG1 (IC50 = 1.5 µM).1 It also displays significant inhibition of another BER enzyme, NTHL1.

References/Citations:

  1. Thacker al. (2026), A SMUG1 Inhibitor Modulates the Excision of Pyrimidine DNA Damage; ACS Med. Chem. Lett., 17 1285