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Sulindac Sulfide | NFkappaB inhibitor

CAS:
32004-67-4
Catalog Number:
10-2156
Activity:
NFkappaB inhibitor
Chemical Name:
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Molecular Weight:
340.42
Molecular Formula:
C20H17FO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Sulindac sulfide (32004-67-4) is the active metabolite of cyclooxygenase inhibitor sulindac.1 Strongly inhibits Ras induced malignant transformation and Ras/Raf dependent transactivation.2 Sulindac sulfide induces apoptosis in cancer cells via PDE5 inhibition.3,4 Modulates beta-cetenin mediated effects.5

References/Citations:

1) Duggan et al. (1977) Identification of the biologically active form of sulindac; J. Pharmacol. Exp. Ther., 201 8
2) Herrmann et al. (2000) Sulindac sulfide inhibits Ras signaling; Nature 17 1769
3) Tinsley et al. (2010) Colon tumor cell growth inhibitory activity of sulindac sulfide and other NSAIDS is associated with PDE5 inhibition; Cancer Prev. Res., 3 1303
4) Tinsley et al. (2011) Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin mediated transcription in human breast tumor cells; Cancer Prev .Res., 4 1275
5) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM3-knockout mice; Proc. Natl. Acad. Sci. USA, 112 8421

Sulindac Sulfide | NFkappaB inhibitor is also available in the Cellular Metabolism Library.
CAS:
32004-67-4
Catalog Number:
10-2156
Activity:
NFkappaB inhibitor
Chemical Name:
(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid
Molecular Weight:
340.42
Molecular Formula:
C20H17FO2S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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