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Sulindac Sulfone | Modulates beta-catenin-mediated effects

Sulindac sulfone (59864-04-9) is a metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2 Modulates beta-catenin mediated effects. 3

References/Citations
1) Thompson et al. (2000) Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation and attenuated beta-catenin. Cancer Res., 60 3338
2) Taylor et al. (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in humancolon cancer cells; Cancer Res. 60 6607
3) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM-3 knockout mice; Proc. Natl. Acad. Sci. USA 112 8421

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Focus Biomolecules supplier, structure Sulindac Sulfone | Modulates beta-catenin-mediated effects | CAS 59864-04-9

Catalog#  10-1122

$50.00
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CAS:
59864-04-9
Catalog Number:
10-1122
Activity:
Modulates beta-catenin-mediated effects
Chemical Name:
(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfonyl)benzylidene]indene-3-acetic acid
Molecular Weight:
372.41
Molecular Formula:
C20H17FO4S
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Yellow solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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