T863 | DGAT1 inhibitor

CAS:
 701232-20-4
Catalog Number:
 10-4460
T863 chemical structure

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T863 (701232-20-4) is a potent (IC50 = 49 nM CPM fluorescent assay; 17 nM TLC assay) and selective (against DGAT2 and MGATs 2 and 3) inhibitor of diacylglycerol transferase 1 (DGAT1). In mice, it caused weight loss, increased insulin sensitivity, alleviated hepatic steatosis, and reduced triglyceride and cholesterol levels.

References/Citations:

  1. Cao et al. (2011), Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecules Inhibitors for the Treatment of Metabolic Diseases; J. Biol. Chem. 286 41838
701232-20-4, DGAT1 inhibitor, selective DGAT1 inhibitor, T863, T863 supplier
CAS:
701232-20-4
Catalog Number:
10-4460
Activity:
DGAT1 inhibitor
Chemical Names:
trans-2-[4-[4-(4-amino-7,7-dimethylpyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl]acetic acid
Molecular Weight:
394.48
Molecular Formula:

C22H26N4O3

Solubility:
Soluble in DMSO (>25 mg/ml)
Physical Properties:
Beige solid
Purity:

98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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T863 (701232-20-4) is a potent (IC50 = 49 nM CPM fluorescent assay; 17 nM TLC assay) and selective (against DGAT2 and MGATs 2 and 3) inhibitor of diacylglycerol transferase 1 (DGAT1). In mice, it caused weight loss, increased insulin sensitivity, alleviated hepatic steatosis, and reduced triglyceride and cholesterol levels.

References/Citations:

  1. Cao et al. (2011), Targeting Acyl-CoA:Diacylglycerol Acyltransferase 1 (DGAT1) with Small Molecules Inhibitors for the Treatment of Metabolic Diseases; J. Biol. Chem. 286 41838

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