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Product Details

Tafamidis | Transthyretin stabilizer

Tafamidis (594839-88-0) is a potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM)1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 μM).1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.

References/Citations
1) Bulawa et al. (2012), Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits amyloid cascade; Proc. Natl. Acad. Sci. USA, 109 9629
2) Scott (2014), Tafamidis: a review of its use in familial amyloid polyneuropathy; Drugs, 74 1371
3) Zhao et al. (2019), Tafamidis, a Noninvasive Therapy for Delaying Transthyretin Familial Amyloid Polyneuropathy: Systemic Review and Meta-analysis; J. Clin. Neurol., 15 108
4) Lorenzini and Elliott (2019), Tafamidis for the treatment of transthyretin amyloidosis; Future Cardiol., 15 53

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Catalog#  10-3743-0005

$60.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
594839-88-0
Catalog Number:
10-3743
Activity:
Transthyretin stabilizer
Chemical Name:
2-(3,5-Dichlorophenyl)-6-benzoxazolecarboxylic acid
Alternate Name:
PF-06291826
Molecular Weight:
308.12
Molecular Formula:
C14H7Cl2NO3
Solubility:
Soluble in DMSO (up to 20 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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