January 25, 2023
In a paper just out in Phytomedicine, HG Kim and coworkers describe the in vitro anti-cancer activity of Beauvericin, an antimicrobial metabolite from the fungus Beauveria […]
January 9, 2023
Apoptolidin is a novel microbial natural product isolated from Nocardiopsis sp. It was shown to be a powerful inducer of apoptosis in a variety of cancer […]
September 23, 2022
Yuki Yoshimatsu and coworkers have shown that they could establish patient-derived cancer cell lines for myxofibrosarcoma and pleomorphic sarcoma. After screening these cell lines with a […]
August 12, 2022
In the August issue of J. Antibiotics (Tokyo) Yoshida and coworkers at the University of Tsukuba reviewed their excellent work on synthesis, SAR, biology and chemical […]
August 1, 2022
Yan and coworkers have demonstrated a potential way to boost innate immune attack on solid tumors. They found that Rocaglamide, a structurally novel natural product, promoted […]
June 15, 2022
JTE-607, a cell-permeable prodrug which is converted to its active COOH form via intracellular esterases, was originally found to inhibit cytokine release but its mechanism of […]
March 25, 2022
Disrupting N-glycan expression on tumor cells enhanced CAR T cell efficacy. Greco et al. treated mice with 2-deoxy-D-glucose (Focus Cat.# 10-2171), a glucose analog, disrupting N-glycan […]
March 23, 2022
The FDA has approved the use of olaparib (Focus Cat.# 10-2154) as adjuvant treatment for patients with BRCA-mutated HER-2 negative high-risk early breast cancer that were […]