Mitapivat is an allosteric activator of red blood cell pyruvate kinase, the enzyme that performs the final step of glycolysis: it catalyzes the conversion of phosphoenolpyruvate […]

Cancer cells modify their metabolism in order to survive and grow. For example, they employ the Warburg effect (increasing glucose uptake and directly converting it to […]

In a fascinating paper just out in Cell Metabolism, Mathias Wenes and coworkers found that the mitochondrial pyruvate carrier (MPC) regulates memory T cell differentiation and […]