April 16, 2026
FOCUS on Mitochondrial Disease. Leigh syndrome (LS) is a mitochondrial disease characterized by neurodevelopmental regression and muscle weakness with early death following metabolic crises. In a […]
February 11, 2026
FOCUS on Parkinson’s Disease: Y Xu and coworkers identified deubiquitinating enzyme USP25 as a susceptible locus for PD as just reported in PNAS. They showed that USP25 […]
September 16, 2025
FOCUS on Mitochondria. This week is World Mitochondrial Disease Week and a great opportunity to focus on Focus Biomolecules’ Targeted Mitochondria Reagents. These unique reagents consist […]
July 12, 2024
Natural Product Cellular Probes. Ascochlorin is a novel isoprenoid isolated from Acremonium egyptiacum. It is a specific inhibitor of the mitochondrial cytochrome bc1 complex (mitochondrial respiratory […]
June 27, 2024
Focus on Bioactive Natural Products: Just out in ACS Chemical Biology, FA Gowans and coworkers at Berkeley reported that ophiobolin A (OPA) covalently targets mitochondrial complex […]
June 12, 2024
An interesting review has just been published in the May 23 issue of Cell by A Suomalainen and J Nunnari entitled “Mitochondria at the Crossroads of […]
March 23, 2023
Journal Club: Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder caused by the expression of progerin, a Lamin A mutant. The study of HGPS […]
September 20, 2022
P. Hiengrach and coworkers recently showed that BAM15, a mitochondrial uncoupling agent, attenuated sepsis in a mouse cecal ligation and puncture model. BAM15 attenuated sepsis as […]