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Tamoxifen citrate | ER Antagonist; GPR30 agonist

Tamoxifen citrate (54965-24-1) is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines1. Displays neuroprotective effects in permanent focal ischemia2. Inhibits PKC3. Potent agonist at GPR30 (membrane estrogen receptor)4. Clinically useful breast cancer agent5.

1) Ferlini et al. (1999), Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines; Br. J. Cancer, 79 257
2) Kimelberg et al. (2003), Neuroprotective activity of tamoxifen in permanent focal ischemia; J. Neurosurg., 99 138
3) Couldwell et al. (1994), Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines; FEBS Lett., 345 43
4) Thomas et al. (2005), Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells; Endocrinology, 146 624
5) Jordan et al. (2006), Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer; Br. J. Pharmacol., 147 S269

Focus Biomolecules cell signaling tech supplier, structure Tamoxifen citrate | ER Antagonist; GPR30 agonist | CAS 54965-24-1

Catalog#  10-1256

Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
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Catalog Number:
ER Antagonist. GPR30 agonist
Alternate Names:
Chemical Name:
(2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Molecular Weight:
Molecular Formula:
C26H29NO C6H8O7
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
99% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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