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Tamoxifen citrate | ER Antagonist; GPR30 agonist

Tamoxifen citrate (54965-24-1) is an estrogen receptor antagonist/partial agonist. Induces oxidative stress and apoptosis in estrogen receptor-negative cancer cell lines1. Displays neuroprotective effects in permanent focal ischemia2. Inhibits PKC3. Potent agonist at GPR30 (membrane estrogen receptor)4. Clinically useful breast cancer agent5.

References/Citations
1) Ferlini et al. (1999), Tamoxifen induces oxidative stress and apoptosis in oestrogen receptor-negative human cancer cell lines; Br. J. Cancer, 79 257
2) Kimelberg et al. (2003), Neuroprotective activity of tamoxifen in permanent focal ischemia; J. Neurosurg., 99 138
3) Couldwell et al. (1994), Protein kinase C inhibitors induce apoptosis in human malignant glioma cell lines; FEBS Lett., 345 43
4) Thomas et al. (2005), Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells; Endocrinology, 146 624
5) Jordan et al. (2006), Tamoxifen (ICI46,474) as a targeted therapy to treat and prevent breast cancer; Br. J. Pharmacol., 147 S269

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Focus Biomolecules cell signaling tech supplier, structure Tamoxifen citrate | ER Antagonist; GPR30 agonist | CAS 54965-24-1

Catalog#  10-1256

$30.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
54965-24-1
Catalog Number:
10-1256
Activity:
ER Antagonist. GPR30 agonist
Alternate Names:
ICI-46474
Chemical Name:
(2)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate
Molecular Weight:
563.65
Molecular Formula:
C26H29NO C6H8O7
Solubility:
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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