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Tanshinone IIA | AP-1 transcription factor inhibitor

Tanshinone IIA (568-72-9) is a diterpenoid naphthoquinone found in Salvia sp. and isolated as an active component of the traditional Chinese medicine Tanshen. Tanshinone IIA displays anti-inflammatory activity1 and induces apoptosis in a variety of cell lines2. Also inhibits AP-1 activity by suppressing jun-fos-DNA complex formation (IC50 = 0.22 μM)3.

References/Citations
1) Kang et al. (2000), Inhibition of interleukin-12 and interferon-gamma production in immune cells by tanshinones from Salvia miltiorrhiza; Immunopharmacology, 49 355
2) Sung et al. (1999), Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3; Exp. Mol. Med., 31 174
3) Park et al. (1999), Suppression of AP-1 Activity by Tanshinone and Cancer Cell Growth Inhibition; Bull. Korean Chem. Soc., 20 925

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Focus Biomolecules supplier, chemical structure of Tanshinone IIA | AP-1 transcription factor inhibitor | CAS 568-72-9

Catalog#  10-2186

$40.00
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CAS:
568-72-9
Catalog Number:
10-2186
Activity:
AP-1 transcription factor inhibitor
Chemical Name:
1,6,6-Trimethyl-6,7,8,9-tetrahydrophenanthro[1,2-b]furan-10.11-dione
Molecular Weight:
294.35
Molecular Formula:
C19H18O3
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml).
Physical Properties:
Orange solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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