Tegaserod maleate | 5-HT₄ agonist/YTHDF1 inhibitor

CAS:
 189188-57-6
Catalog Number:
 10-4876

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Tegaserod (189188-57-6) is a potent and selective partial agonist of the serotonin 5-HT4 receptor.1,2 Tegaserod is an inhibitor of the RNA m6A reader YTHDF1.3 It reduced the viability of patient-derived AML cells and prolonged survival in xenograft models. Tegaserod also suppressed tumor growth in various models via inhibition of sonic hedgehog signaling4, MEK1/25, peroxisome pathway6, and others7.

References/Citations:

  1. Buchheit et al. (1995), The Serotonin 5-HT4 Receptor. 2. Structure-Activity Studies of the Indole Carbazimidamide Class of Agonists; J. Med. Chem. 38 2331
  2. Scott and Perry (1999), Tegaserod; Drugs 58 491
  3. Hong et al. (2023), The RNA m6A Reader YTHDF1 is Required for Acute Myeloid Leukemia Progression; Cancer Res. 83 845
  4. Cai et al. (2025), Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway; Mol. Med. 31 30
  5. Wang et al. (2022), Tegaserod Maleate Suppresses the Growth of Gastric Cancer In vivo and In Vitro by Targeting MEK1/2; Cancers (Basel) 14 3592
  6. Wu et al. (2021), Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway; Front. Oncol. 11 683241
  7. Li et al. (2022), Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy; J. Oncol. 2022 5320421
189188-57-6, tegaserod, Tegaserod maleate supplier, YTHDF1 inhibitor
CAS:
189188-57-6
Catalog Number:
10-4876
Activity:
5-HT4 agonist/YTHDF1 inhibitor
Chemical Names:
1-[(E)-(5-Methoxy-1H-indol-3-yl)methylideneamino]-2-pentylguanidine maleate
Alternate Name:
SDZ HTF 919
Molecular Weight:
417.47
Molecular Formula:

C16H23N5O·C4H4O4

Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
Pale yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Tegaserod (189188-57-6) is a potent and selective partial agonist of the serotonin 5-HT4 receptor.1,2 Tegaserod is an inhibitor of the RNA m6A reader YTHDF1.3 It reduced the viability of patient-derived AML cells and prolonged survival in xenograft models. Tegaserod also suppressed tumor growth in various models via inhibition of sonic hedgehog signaling4, MEK1/25, peroxisome pathway6, and others7.

References/Citations:

  1. Buchheit et al. (1995), The Serotonin 5-HT4 Receptor. 2. Structure-Activity Studies of the Indole Carbazimidamide Class of Agonists; J. Med. Chem. 38 2331
  2. Scott and Perry (1999), Tegaserod; Drugs 58 491
  3. Hong et al. (2023), The RNA m6A Reader YTHDF1 is Required for Acute Myeloid Leukemia Progression; Cancer Res. 83 845
  4. Cai et al. (2025), Tegaserod maleate exerts anti-tumor effects on prostate cancer via repressing sonic hedgehog signaling pathway; Mol. Med. 31 30
  5. Wang et al. (2022), Tegaserod Maleate Suppresses the Growth of Gastric Cancer In vivo and In Vitro by Targeting MEK1/2; Cancers (Basel) 14 3592
  6. Wu et al. (2021), Tegaserod Maleate Inhibits Esophageal Squamous Cell Carcinoma Proliferation by Suppressing the Peroxisome Pathway; Front. Oncol. 11 683241
  7. Li et al. (2022), Tegaserod Maleate Inhibits Breast Cancer Progression and Enhances the Sensitivity of Immunotherapy; J. Oncol. 2022 5320421

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