Tetrabenazine | VMAT2 inhibitor
NMR (Conforms)
Available Options
| Size : | Price | Quantity | |
|---|---|---|---|
| 10 mg | $30.00 | ||
| 50 mg | $80.00 |
Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.4
References/Citations:
1) Scherman et al. (1983), Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine; Proc. Natl. Acad. Sci. USA, 80 584
2) Peter et al. (1996), Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine; J. Biol. Chem., 271 2979
3) Schafer et al. (2013), Localization and expression of VMAT2 across mammalian species: a translational guide for it’s visualization and targeting in health and disease; Adv. Pharmacol., 68 319
4) Sakano et al. (2014), VMAT2 identified as a regulator of late-stage β-cell differentiation; Nat. Chem. Biol., 10 141
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
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Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.4
References/Citations:
1) Scherman et al. (1983), Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine; Proc. Natl. Acad. Sci. USA, 80 584
2) Peter et al. (1996), Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine; J. Biol. Chem., 271 2979
3) Schafer et al. (2013), Localization and expression of VMAT2 across mammalian species: a translational guide for it’s visualization and targeting in health and disease; Adv. Pharmacol., 68 319
4) Sakano et al. (2014), VMAT2 identified as a regulator of late-stage β-cell differentiation; Nat. Chem. Biol., 10 141
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