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Tetrabenazine | VMAT2 inhibitor

Tetrabenazine (58-46-8) is a potent inhibitor of the vesicular monoamine transporter (VMAT), IC50=3.2 nM1,2 with selectivity for VMAT2 over VMAT13. Promotes late stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3-positive endocrine precursors.4.

1) Scherman et al. (1983), Characterization of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine; Proc. Natl. Acad. Sci. USA, 80 584
2) Peter et al. (1996), Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine; J. Biol. Chem., 271 2979
3) Schafer et al. (2013), Localization and expression of VMAT2 across mammalian species: a translational guide for it's visualization and targeting in health and disease; Adv. Pharmacol., 68 319
4) Sakano et al. (2014), VMAT2 identified as a regulator of late-stage β-cell differentiation; Nat. Chem. Biol., 10 141

Focus Biomolecules cell signaling reagent supplier, chemical structure of Tetrabenazine | VMAT2 inhibitor | CAS 58-46-8

Catalog#  10-2672-0010

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Catalog Number:
VMAT2 inhibitor
Chemical Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 9 mg/ml).
Physical Properties:
White solid
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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