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Product Details

TG 4-155 | EP2 receptor antagonist

TG 4-155 (1164462-05-8) is a potent and selective prostaglandin EP2 receptor antagonist, KB = 2.4 and 34.5 nM for EP2 and DP1 receptors respectively. Displays >500-fold selectivity for EP2 over other prostanoid receptors.1 Inhibits butaprost-induced proinflammatory cytokine production, cell proliferation and invasion of PC-3 cells in vitro.2 Inhibits PGE2-induced inflammatory response and may represent a novel pharmacologic intervention for tumorigenesis resulting from inflammation.1

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References/Citations

1) Jiang and Dingledine (2013), Role of prostaglandin receptor EP2 in the regulations of cancer cell proliferation, invasion, and inflammation; J. Pharmacol. Exp. Ther. 344 360
2) Quan et al. (2013), EP2 Receptor Signaling Pathways Regulate Classical Activation of Microglia; J. Biol. Chem. 288 9293

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Focus Biomolecules cell signaling reagent supplier, chemical structure TG 4-155 | EP2 receptor antagonist | CAS 1164462-05-8

Catalog#  10-1574-0005

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1164462-05-8
Catalog Number:
10-1574
Activity:
EP2 receptor antagonist
Chemical Name:
(2E)-N-[2-(2-Methyl-1H-indol-1-yl)ethyl]-3-(3,4,5-trimethoxyphenyl)-2-propenamide
Molecular Weight:
394.47
Molecular Formula:
C23H26N2O4
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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