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Product Details

TGN-020 | Aquaporin 4 blocker

TGN-020 (51987-99-6) is an aquaporin 4 channel blocker, IC50 = 3.1 μM.1 Reduces ischemic cerebral edema in a mouse model of focal cerebral ischemia using MRI.2 TGN-020 increases regional cerebral blood flow as determined in wild-type and AQP-4 knockout mice.3  Reduces brain edema when administered after onset of ischemia in rat models.4

References/Citations
1) Huber et al. (2009), Identification of aquaporin 4 inhibitors using in vitro and in silico methods; Bioorg. Med. Chem., 17 411
2) Igarashi et al. (2011), Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema; Neurol. Sci., 32 113
3) Igarashi et al. (2013), Inhibition of aquaporin-4 significantly increases regional cerebral blood flow; Infect. Neuroreport, 24 324
4) Pirici et al. (2017), Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways; Int. J. Mol. Sci., 19 E46

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Focus Biomolecules cell signaling reagent supplier, chemical structure of TGN-020 | Aquaporin 4 blocker | CAS 51987-99-6

Catalog#  10-1546

$75.00
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CAS:
51987-99-6
Catalog Number:
10-1546
Activity:
Aquaporin 4 blocker
Chemical Name:
N-1,3,4-Thiadiazol-2-yl-3-pyridinecarboxamide
Molecular Weight:
206.22
Molecular Formula:
C8H6N4OS
Solubility:
Soluble in DMSO (up to 10 mg/ml with warming)
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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