my account
Login
  Loading... Please wait...

Product Details

Thapsigargin | SERCA inhibitor

Thapsigargin (67526-95-8) is a potent inhibitor of sarco-endoplasmic reticulum Ca2+ -ATPase1. (IC50= 30 nM) Induces endoplasmic reticulum stress and autophagy in a variety of cell lines2. Warning: Thapsigargin is highly irritating to skin and mucus membranes.

References/Citations
1) Treiman et al. (1998), A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases; Trends Pharmacol. Sci., 19 131
2) Zhou et al. (2009), Autophagy-mediated insulin receptor down-regulation contributes to endoplasmic reticulum stress-induced insulin resistance; Mol. Pharmacol., 76 596

swipe
Focus Biomolecules cell signaling reagent supplier, chemical structure of Thapsigargin | SERCA inhibitor | CAS 67526-95-8

Catalog#  10-2105

$58.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
67526-95-8
Catalog Number:
10-2105
Activity:
SERCA inhibitor
Chemical Name:
Isolated from Thapsia garganica
Molecular Weight:
650.77
Molecular Formula:
C34H50O12
Solubility:
Soluble in DMSO (up to 65 mg/ml) or in Ethanol (up to 20 mg/ml).
Physical Properties:
Colorless waxy solid / film
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Thapsigargin | SERCA inhibitor to your wish list.