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Product Details

Thiamet G | O-GlcNAcase alpha 1 antagonist

Thiamet G (1009816-48-1) is a potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Increases levels of O-GlcNAc-modified proteins in cellular assays and in vivo. Suppresses phosphorylation of tau protein in rat cortex and hippocampus.1 Stabilizes tau against aggregation and slows neurodegeneration.2 Thiamet G prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice.3 Active in vivo and blood brain barrier permeable.

References/Citations

1) Yuzwa et al. (2008), A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo; Nat. Chem. Biol., 4 483
2) Yuzwa et al. (2012), Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation; Nat. Chem. Biol. 8 393
3) Yuzwa et al. (2014), Pharmacological inhibition of O-GlcNAcase (OGA) prevents cognitive decline and amyloid plaque formation in bigenic tau/APP mutant mice; Mol. Neurodegener., 9 42

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Focus Biomolecules cell signaling supplier, chemical structure Thiamet G | O-GlcNAcase antagonist | CAS 1009816-48-1

Catalog#  10-2824-0005

$70.00
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CAS:
1009816-48-1
Catalog Number:
10-2824
Activity:
O-GlcNAcase alpha 1 antagonist
Chemical Name:
(3aR,5R,6S,7R,7aR)-2-(Ethylamino)-3a,6,7,7a-tetrahydro-5-(hydroxymethyl)-5H-Pyrano[3,2-d]thiazole-6,7-diol
Molecular Weight:
248.30
Molecular Formula:
C9H16N2O4S
Solubility:
Soluble in DMSO (up to 10 mg/ml)
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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