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Tianeptine sodium salt | Neuroprotective agent

Tianeptine sodium salt (30123-17-2) is a selective enhancer of serotonin uptake in the brain with no effect on noradrenalin or dopamine uptake.1 Clinically useful antidepressant.2 Displays neuroprotective effects against hypoxia in cell culture and against the deleterious effects of cytokines in vivo.3 Induces mTORC1 activation in rat hippocampal neurons and increases dendritic outgrowth, spine density and synaptic proteins.4 Attenuates LPS-evoked inflammatory activation of microglial cells in culture.5


1) Mennini et al. (1987), Tianeptine, a selective enhancer of serotonin uptake in rat brain;  Naunyn-Schmied. Arch. Pharmacol., 336 478
2) Kato and Weitsch (1988), Neurochemical profile of tianeptine, a new antidepressant drug;  Clin. Neuropharmacol., 11 S43
3) Plaisant et al. (2003), Neuroprotective properties of tianeptine: interactions with cytokines; Neuropharmacology, 44 801
4) Seo et al. (2016), Tianeptine induces mTORC1 activation in rat hippocampal neurons under toxic conditions;  Psychopharmacology (Berl.), 233 2617
5) Slusarczyk et al. (2017), Anti-inflammatory properties of tianeptine on lipopolysaccharide-induced changes in microglial cells involve toll-like receptor-related pathways;  J. Neurochem., 136 958

Focus Biomolecules supplier, chemical structure of Tianeptine sodium salt | Neuroprotective agent | CAS 30123-17-2

Catalog#  10-2937-0010

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Catalog Number:
Neuroprotective agent
Chemical Name:
7-[(3-chloro-6,11-dihydro-6-methyl-5,5-dioxidibenzo[c,f][1,2]thiazepin-11-yl)amino]heptamoic acid, sodium salt
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 5 mg/ml) or in Water (up to 45 mg/ml)
Physical Properties:
White solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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