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Product Details

TIC10 | Mitochondrial caseinolytic protease P activator / Anticancer agent

TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell death.1-3  TIC10 potently activates mitochondrial caseinolytic protease P (ClpP) causing eIF2α-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis.4 Currently in clinical trials.

References/Citations
1) Allen et al. (2013) Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects, Sci. Transl. Med. 5 171ra17
2) Allen et al. (2015) Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway, Mol. Cancer. 14 99
3) Allen et al. (2016) Discovery and Clinical Introduction of First-In-Class Imipridone ONC201, Oncotarget 7 74380
4) Ishizawa et al. (2019) Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality, Cancer Cell 35 721

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Catalog#  10-4090-0005

$50.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1616632-77-9
Catalog Number:
10-4090
Activity:
Mitochondrial caseinolytic protease P activator / Anticancer agent
Chemical Name:
7-Benzyl-4-(2-methylbenzyl)-1,2,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one
Alternate Name:
ONC201
Molecular Weight:
386.49
Molecular Formula:
C24H26N4O
Solubility:
Soluble in DMSO (up to 25 mg/ml with warming).
Physical Properties:
Pale yellow solid
Purity:
98% by TLC
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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