TIC10 | Mitochondrial caseinolytic protease P activator / Anticancer agent
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $55.00 | ||
| 25 mg | $200.00 |
TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell death.1-3 TIC10 potently activates mitochondrial caseinolytic protease P (ClpP) causing eIF2α-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis.4 Currently in clinical trials.
References/Citations:
1) Allen et al. (2013) Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects, Sci. Transl. Med. 5 171ra17
2) Allen et al. (2015) Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway, Mol. Cancer. 14 99
3) Allen et al. (2016) Discovery and Clinical Introduction of First-In-Class Imipridone ONC201, Oncotarget 7 74380
4) Ishizawa et al. (2019) Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality, Cancer Cell 35 721
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TIC10 (1616632-77-9) is novel anti-cancer compound that acts via early-stage integrated stress response activation leading to selective cancer cell death.1-3 TIC10 potently activates mitochondrial caseinolytic protease P (ClpP) causing eIF2α-independent induction of ATF4 and Akt/ERK/Foxo3a/DR5/TRAIL-dependent apoptosis.4 Currently in clinical trials.
References/Citations:
1) Allen et al. (2013) Dual Inactivation of Akt and ERK by TIC10 Signals Foxo3a Nuclear Translocation, TRAIL Gene Induction, and Potent Antitumor Effects, Sci. Transl. Med. 5 171ra17
2) Allen et al. (2015) Identification of TRAIL-inducing compounds highlights small molecule ONC201/TIC10 as a unique anti-cancer agent that activates the TRAIL pathway, Mol. Cancer. 14 99
3) Allen et al. (2016) Discovery and Clinical Introduction of First-In-Class Imipridone ONC201, Oncotarget 7 74380
4) Ishizawa et al. (2019) Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality, Cancer Cell 35 721
Related products
-
AZD7762 | Checkpoint kinase 1/2 inhibitor
From $60.00CAS:860352-01-8 (free base)Catalog Number:10-4771Activity:Checkpoint kinase 1/2 inhibitorChemical Name:3-(Carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide hydrochlorideMolecular Weight:398.88Molecular Formula:C17H19FN4O2S • HClSolubility:Soluble in DMSO (up to at least 25 mg/ml).Physical Properties:Yellow or brown solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.Shipping Code:RT -
TCEP HCl | Reducing agent
From $35.00CAS:51805-45-9Catalog Number:10-2961Activity:Reducing agentChemical Name:Tris(-Carboxyethyl)phosphine HClMolecular Weight:286.65Molecular Formula:C9H15O6P • HClSolubility:Soluble in Water (up to 50 mg/ml)Physical Properties:White solidPurity:99% by TLC
NMR (Conforms)Storage Temperature:-20°CStability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.Shipping Code:RT -
AZ3146 | Mps1 kinase inhibitor
From $60.00CAS:1124329-14-1Catalog Number:10-4778Activity:Mps1 kinase inhibitorChemical Name:9-Cyclopentyl-2-[2-methoxy-4-(1-methylpiperidine-4-yl)oxyanilino]-7-methylpurin-8-oneMolecular Weight:452.56Molecular Formula:C24H32N6O3S2Solubility:Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)Physical Properties:Off-white solidPurity:98% by HPLC
NMR (Conforms)Storage Temperature:-20°Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.