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Product Details

TM-2-51 | HDAC8 activator

TM-2-51 (4921-82-8) is a highly potent and isozyme selective activator of recombinant HDAC8. Increases the activity of HDAC8 by a factor of 12 at 10 μM. No activation of other HDACs is observed. TM-2-51 rescues the activity of catalytically compromised HDAC8 mutants in vitro.2

References/Citations
1) Singh et al. (2011), Histone deacetylase activators: N-acetylthioureas as highly potent and isozyme selective activators for human histone deacetylase-8 on a fluorescent substrate; Bioorg. Med. Chem. Lett., 21 5920
2) Decross et al. (2014), Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders; ACS Chem. Biol., 9 2157
3) Singh et al. (2015), Mechanism of N-acylthiourea Mediated Activation of Human Histone Deacetylase 8 (HDAC8) at Molecular and Cellular Levels; J. Biol. Chem., 290 6607

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TM-2-51 | 4921-82-8 | Structure | Supplier

Catalog#  10-1522

$50.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
4921-82-8
Catalog Number:
10-1522
Activity:
HDAC8 activator
Chemical Name:
1-Benzoyl-3-phenyl-2-thiourea
Molecular Weight:
256.32
Molecular Formula:
C14H12N2OS
Solubility:
Soluble in DMSO (greater than 50 mg/ml) or in Ethanol (up to 8 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSOor ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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