TM-25659 | TAZ activator

CAS:
 260553-97-7
Catalog Number:
 10-4293

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TM-25659 (260553-97-7) is a TAZ activator that significantly increases TAZ nuclear localization.  It suppressed PPARγ-dependent adipogenesis and enhanced osteoblast differentiation in vitro and in vivo.1 TM-25659 decreased insulin resistance and inflammation in mice via activation of GCN2 pathways.2 It promoted osteogenic differentiation in both adipose-derived stem cells3 and mesenchymal stem cells4.

References/Citations:

  1. Jang et al. (2012), TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ; Br. J. Pharmacol. 165 1584
  2. Jung et al. (2015), TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways; Mol. Cells 38 1037
  3. Zhu et al. (2018), Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells; Stem Cell Res. Ther. 9 53
  4. Huang et al. (2022), TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cell lines C2C12, and MEFs induced by BMP9; Cell Death Discov. 8 499
260553-97-7, TAZ activator, TM-25659, TM-25659 supplier, TM25659
CAS:
260553-97-7
Catalog Number:
10-4293
Activity:
TAZ activator
Chemical Names:
2-Butyl-5-methyl-6-pyridin-3-yl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazo[4,5-b]pyridine
Molecular Weight:
500.61
Molecular Formula:

C30H28N8

Solubility:
Soluble in DMSO (>50 mg/ml)
Physical Properties:
Off-white solid
Purity:

98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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TM-25659 (260553-97-7) is a TAZ activator that significantly increases TAZ nuclear localization.  It suppressed PPARγ-dependent adipogenesis and enhanced osteoblast differentiation in vitro and in vivo.1 TM-25659 decreased insulin resistance and inflammation in mice via activation of GCN2 pathways.2 It promoted osteogenic differentiation in both adipose-derived stem cells3 and mesenchymal stem cells4.

References/Citations:

  1. Jang et al. (2012), TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ; Br. J. Pharmacol. 165 1584
  2. Jung et al. (2015), TM-25659-Induced Activation of FGF21 Level Decreases Insulin Resistance and Inflammation in Skeletal Muscle via GCN2 Pathways; Mol. Cells 38 1037
  3. Zhu et al. (2018), Pharmacological activation of TAZ enhances osteogenic differentiation and bone formation of adipose-derived stem cells; Stem Cell Res. Ther. 9 53
  4. Huang et al. (2022), TAZ promotes osteogenic differentiation of mesenchymal stem cells line C3H10T1/2, murine multi-lineage cell lines C2C12, and MEFs induced by BMP9; Cell Death Discov. 8 499

STEM CELL

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