TN-2-30 | Facilitates GMP expansion

CAS:
 943820-93-7
Catalog Number:
 10-4893
TN-2-30 chemical structure

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TN-2-30 (943820-93-7) is part of the chemical cocktail SCF/2i-IG that enables the long-term expansion of mouse and human granulocyte-monocyte progenitor (GMP) cells.1 This cocktail allows extensive clonal expansion while retaining canonical immunophenotype, GMP-like chromatin and transcriptional profiles, and intact myeloid differentiation outputs.  TN-2-30 was found to contribute to these effects via myeloperoxidase inhibition. TN-2-30 was originally found to be a Wnt/ß-catenin agonist2, but this pathway was not involved in the enhancement of clonal expansion. An interesting new tool for exploring the use of expandable GMPs for engineered tumor immunotherapy.

References/Citations:

  1. Yue et al. (2026), Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy; Cell, 189 5378
  2. Cho et al. (2007), Isoxazole derivatives and use thereof; WO2007078113A1
9433820-93-7, GMP clonal expansion, MPO inhibitor, myeloperoxidase inhibitor, TN-2-30, TN-2-30 supplier
CAS:
943820-93-7
Catalog Number:
10-4893
Activity:
Facilitates GMP expansion
Chemical Names:
5-(2-Furanyl)-N-[2-(1H-pyrazol-1-yl)ethyl]-3-isoxazolecarboxamide
Molecular Weight:
272.26
Molecular Formula:

C13H12N4O3

Solubility:
Soluble in DMSO (60 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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TN-2-30 (943820-93-7) is part of the chemical cocktail SCF/2i-IG that enables the long-term expansion of mouse and human granulocyte-monocyte progenitor (GMP) cells.1 This cocktail allows extensive clonal expansion while retaining canonical immunophenotype, GMP-like chromatin and transcriptional profiles, and intact myeloid differentiation outputs.  TN-2-30 was found to contribute to these effects via myeloperoxidase inhibition. TN-2-30 was originally found to be a Wnt/ß-catenin agonist2, but this pathway was not involved in the enhancement of clonal expansion. An interesting new tool for exploring the use of expandable GMPs for engineered tumor immunotherapy.

References/Citations:

  1. Yue et al. (2026), Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy; Cell, 189 5378
  2. Cho et al. (2007), Isoxazole derivatives and use thereof; WO2007078113A1

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