TP-040 | O-GlcNAcase inhibitor

CAS:
 2757254-99-0
Catalog Number:
 10-4289
TP-040 chemical structure

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TP-040 (2757254-99-0) is a potent and brain-penetrant inhibitor (IC50 = 46 nM) of O-GlcNAcase (OGA).  OGA catalyzes the cleavage of O-linked N-acetylglucosamine from serine and threonine residues. On tau proteins, this leads to a less soluble and less stable protein form that is prone to aggregation.  TP-040 is an interesting new tool for studying the effects of tau protein aggregation in neurodegenerative diseases.

References/Citations:

  1. Tawada et al. (2021), Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization; J. Med. Chem., 53 1103
2757254-99-0, O-GlcNAcase inhibitor, O-GlcNAcase-IN-1, O-GlcNAcase-IN-1 supplier, OGA inhibitor, TP-040, TP-040 supplier, TP040
CAS:
2757254-99-0
Catalog Number:
10-4289
Activity:
O-GlcNAcase inhibitor
Chemical Names:
N-((1-Methyl-1H-imidazol-4-yl)methyl)-4-(4-methylpiperidin-1-yl)pyrimidin-2-amine
Alternate Name:
O-GlcNAcase-IN-1
Molecular Weight:
286.38
Molecular Formula:

C15H22N6

Solubility:
Soluble in DMSO (20 mg/ml)
Physical Properties:
White to off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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TP-040 (2757254-99-0) is a potent and brain-penetrant inhibitor (IC50 = 46 nM) of O-GlcNAcase (OGA).  OGA catalyzes the cleavage of O-linked N-acetylglucosamine from serine and threonine residues. On tau proteins, this leads to a less soluble and less stable protein form that is prone to aggregation.  TP-040 is an interesting new tool for studying the effects of tau protein aggregation in neurodegenerative diseases.

References/Citations:

  1. Tawada et al. (2021), Discovery of a Novel and Brain-Penetrant O-GlcNAcase Inhibitor via Virtual Screening, Structure-Based Analysis, and Rational Lead Optimization; J. Med. Chem., 53 1103

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